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Seminario – Sandra Jurado Sánchez

Oxytocin is a neuropeptide hormone synthesized in the hypothalamus involved in the modulation of vital homeostatic functions and complex behaviors such as social conduct, one of the aspects that have contributed to its popularity with adjectives like the “love hormone” or the “molecule of friendship.”

However, despite its important role as a neuromodulator, many details of the functioning and regulation of the oxytocinergic system remain unknown. Basic questions such as the specification of these circuits during development or how the release of oxytocin is controlled in response to different stimuli continue to be subjects of intense exploration. Advancing the knowledge of this type of signaling is of vital importance, as the alteration of these circuits has been related to numerous social behavior disorders such as autism or social anxiety.

In this seminar, I will present the latest advances made by my laboratory in the study of the oxytocin system. Our group implements innovative techniques that range from the reconstruction of circuits in 3D in the whole brain to in vivo molecular manipulations and behavioral analysis, with the aim of analyzing the formation of these systems during development, their plastic properties, and degeneration during healthy and pathological aging. These studies contribute to the basic understanding of the functioning of the oxytocin system and provide the building blocks for the development of new therapeutic strategies for the treatment of social deficits.

Publicaciones relacionadas

Assessment of social behavior and chemosensory cue detection in an animal model of neurodegeneration.
Portalés A, Sánchez-Aguilera A, Royo M, Jurado S.
Methods Cell Biol. 2024;185:137-150. 

Natural and Pathological Aging Distinctively Impacts the Pheromone Detection System and Social Behavior.
Portalés A, Chamero P, Jurado S.
Mol Neurobiol. 2023 Aug;60(8):4641-4658. doi: 10.1007/s12035-023-03362-3.

Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain.

Madrigal MP, Jurado S.
Commun Biol. 2021 May 14;4(1):586. doi: 10.1038/s42003-021-02110-4

Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms.
Arendt KL, Zhang Y, Jurado S, Malenka RC, Südhof TC, Chen L.
Neuron. 2015 Apr 22;86(2):442-56. 

Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens.
Schwartz N, Temkin P, Jurado S, Lim BK, Heifets BD, Polepalli JS, Malenka RC.
Science. 2014 Aug 1;345(6196):535-42.

LTP requires a unique postsynaptic SNARE fusion machinery.

Jurado S, Goswami D, Zhang Y, Molina AJ, Südhof TC, Malenka RC.
Neuron. 2013 Feb 6;77(3):542-58. doi: 10.1016/j.neuron.2012.11.029.

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression.
Jurado S, Biou V, Malenka RC.
Nat Neurosci. 2010 Sep;13(9):1053-5. doi: 10.1038/nn.2613.