Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) is a powerful technique that allows access to fine microstructural details in a non invasive fashion. In this talk, I will introduce DW-MRI most important concepts, and describe in detail our recent work using DW-MRI to look at microglia and astrocyte morphology in the brain of rodents following an immune challenge, and axonal diameter in both animal models of axonal pathology, and a cohort of multiple sclerosis patients.
Related Publications:
- A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis.Cerdán Cerdá A, Toschi N, Treaba CA, Barletta V, Herranz E, Mehndiratta A, Gomez-Sanchez JA, Mainero C & De Santis S. eLife 2024(2024) 13 https://doi.org/10.7554/eLife.79169
- Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena , Mark Drakesmith2, Kristin Koller, Derek K Jones , Santiago Canals , Silvia De Santis Sci Adv. 20228(21):eabq2923 https://doi.org/10.1126/sciadv.abq2923